Anti-PDGFR α antibody produced in rabbit
SIGMA/SAB4502139 - affinity isolated antibody
Synonym: α platelet-derived growth factor receptor precursor; CD140a; PDGF-R-α; PDGFR-α; kinase PDGFR-α
MDL Number: MFCD01322518
Product Type: Chemical
Immunohistochemistry Anti-PDGFR α: Cat. No. SAB4502139: Immunohistochemistry analysis of paraffin-embedded human brain tissue using Anti-PDGFR α antibody. Cells on the left were treated with the Anti-PDGFR α antibody. Cells on the right (negative control) were treated with both Anti-PDGFR α antibody and the synthesized immunogen peptide.
Immunofluorescence Anti-PDGFR α: Cat. No. SAB4502139: Immunofluorescence of HeLa cells using Anti-PDGFR α antibody. Cells on the left were treated with the Anti-PDGFR α antibody. Cells on the right (negative control) were treated with both Anti-PDGFR α antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 122 kDa |
| NCBI accession no. | P16234   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:5000 |
| immunofluorescence: 1:100-1:500 | |
| immunohistochemistry: 1:50-1:100 |
| Biochem/physiol Actions: | Platelet-derived growth factor receptor plays a vital role in the development and maturation of platelets. Platelet-derived growth factor receptor α (PDGFRA) acts as a potential target for imatinib, a revolutionary drug for the treatment of chronic myeloid leukemia. PDGFRA pathway might be involved in developmental process of thrombocytes. The encoded protein facilitates hepatic stellate cell (HSCs) proliferation and migration. Mutation in the gene has been observed in gastrointestinal stromal tumors (GISTs). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-PDGFR Anti-PDGFR α Antibody detects endogenous levels of total PDGFR α protein. Antibody detects endogenous levels of total PDGFR α protein. |
| General description: | Platelet-derived growth factor receptor α (PDGFRA), also known as cluster of differentiation 140a (CD140a), is encoded by the gene mapped to human chromosome 4q12. The encoded protein belongs to the receptor tyrosine kinase gene family. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human PDGFR alpha. Immunogen Range: 731-780 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |