Anti-PDGFR β antibody produced in rabbit
SIGMA/SAB4502148 - affinity isolated antibody
Synonym: CD140b; PDGF-R-β; PDGFR; PDGFR-β; kinase PDGFR-β
Product Type: Chemical
Immunohistochemistry Anti-PDGFR β: Cat. No. SAB4502148: Immunohistochemistry analysis of paraffin-embedded human brain tissue using Anti-PDGFR β antibody. Cells on the left were treated with the Anti-PDGFR β antibody. Cells on the right (negative control) were treated with both Anti-PDGFR β antibody and the synthesized immunogen peptide.
Immunofluorescence Anti-PDGFR β: Cat. No. SAB4502148: Immunofluorescence of COS7 cells using Anti-PDGFR β antibody. Cells on the left were treated with the Anti-PDGFR β antibody. Cells on the right (negative control) were treated with both Anti-PDGFR β antibody and the synthesized immunogen peptide.
Western Blotting Anti-PDGFR β: Cat. No. SAB4502148: Immunoblotting analysis of extracts from LOVO cells, treated with H2O2 100uM 30′, using Anti-PDGFR β antibody. The lane on the left was treated with the Anti-PDGFR β antibody. The lane on the right (negative control) was treated with both Anti-PDGFR β antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 123 kDa |
| NCBI accession no. | P09619   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, human, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:1000 |
| immunofluorescence: 1:100-1:500 | |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P09619 |
| Biochem/physiol Actions: | PDGFRB (platelet-derived growth factor receptor β), upon interaction with PGDFB, regulates multiple processes such as, sclerotic disorders, wound healing and tumor angiogenesis. Gain-of-function mutation in this gene is linked with Penttinen syndrome. Loss-of-function mutation in this gene results in the neurodegenerative disorder primary familial brain calcification (PFBC). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | PDGFRB (platelet-derived growth factor receptor β) is a type III tyrosine kinase receptor, which exists as a homodimer. This receptor interacts with multiple ligands, but its main physiological ligand is PDGF-BB homodimer. It is located on human chromosome 5q32. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human PDGFR beta. Immunogen Range: 991-1040 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |