Anti-PDGF Receptor β antibody produced in rabbit
SIGMA/SAB4502149 - affinity isolated antibody
Synonym: CD140b; PDGF-R-β; PDGFR; PDGFR-β; kinase PDGFR-β
MDL Number: MFCD00164777
Product Type: Chemical
Immunohistochemistry Anti-PDGF Receptor β: Cat. No. SAB4502149: Immunohistochemistry analysis of paraffin-embedded human brain tissue using Anti-PDGF Receptor β antibody. Cells on the left were treated with the Anti-PDGF Receptor β antibody. Cells on the right (negative control) were treated with both Anti-PDGF Receptor β antibody and the synthesized immunogen peptide.
Immunofluorescence Anti-PDGF Receptor β: Cat. No. SAB4502149: Immunofluorescence of HepG2 cells using Anti-PDGF Receptor β antibody. Cells on the left were treated with the Anti-PDGF Receptor β antibody. Cells on the right (negative control) were treated with both Anti-PDGF Receptor β antibody and the synthesized immunogen peptide.
Western Blotting Anti-PDGF Receptor β: Cat. No. SAB4502149: Immunoblotting analysis of extracts from LOVO cells, using Anti-PDGF Receptor β antibody. The lane on the left was treated with the Anti-PDGF Receptor β antibody. The lane on the right (negative control) was treated with both Anti-PDGF Receptor β antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 123 kDa |
| NCBI accession no. | P09619   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:40000 |
| immunofluorescence: 1:100-1:500 | |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P09619 |
| Biochem/physiol Actions: | PDGFRB (platelet-derived growth factor β) has its key role in cell proliferation, differentiation and survival. It also mediates cell movement and tissue repair mechanism. PDGFβ functions as a mitogen, by binding to the PDGF receptor β. Variation in PDGFRB gene leads to a number of cancer types including glioblastoma, dermatofibrosarcoma, medulloblastoma and endocrine pancreatic tumor. PDGFR-β signaling pathway, can thus serve as an important target for cancer therapy. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | The PDGFRB (platelet-derived growth factor receptor β) gene is mapped to human chromosome 5q32. The encoded protein is a cell surface tyrosine kinase receptor. Anti-PDGF receptor β antibody detects endogenous levels of total PDGF receptor β protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human PDGF Receptor beta. Immunogen Range: 718-767 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |