Anti-PMP22 antibody produced in rabbit
SIGMA/SAB4502217 - affinity isolated antibody
Synonym: GAS3; GROWTH ARREST-SPECIFIC 3
Product Type: Chemical
Immunohistochemistry Anti-PMP22: Cat. No. SAB4502217: Immunohistochemistry analysis of paraffin-embedded human brain tissue using Anti-PMP22 antibody. Cells on the left were treated with the Anti-PMP22 antibody. Cells on the right (negative control) were treated with both Anti-PMP22 antibody and the synthesized immunogen peptide.
Western Blotting Anti-PMP22: Cat. No. SAB4502217: Immunoblotting analysis of extracts from MDA-MB-435 cells, using Anti-PMP22 antibody. The lane on the left was treated with the Anti-PMP22 antibody. The lane on the right (negative control) was treated with both Anti-PMP22 antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous glycerol solution |
| mol wt | 17 kDa |
| NCBI accession no. | Q01453   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:40000 |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | Q01453 |
| Application: | Anti-PMP22 antibody produced in rabbit has been used in: • immunofluorescence • western blotting • immunohistochemistry |
| Application: | Anti-PMP22, C-Terminal antibody produced in rabbit has been used in immunofluorescence analysis. |
| Biochem/physiol Actions: | Peripheral myelin protein 22 (PMP22) plays a vital role in myelination during development of peripheral nerve, cell–cell interactions, cell proliferation, maintenance of axons and the determination of myelin thickness and stability. Biological function of PMP22, might include formation and or maintenance of intercellular junctions and possibly of tight junctions (TJs). Aberrations, duplications or mutations in PMP22 gene lead to majority of heritable demyelinating peripheral neuropathies, such as Charcot-Marie-tooth disease type IA (CMT1A) and Dejerine-Sottas syndrome. PMP2, might be involved in regulation of Schwann cell proliferation and differentiation.5 Overexpression of PMP22 might contribute to the development of chronic myeloid leukemia (CML). PMP22 might, thus, act as a therapeutic target for the treatment of CML. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-PMP22 Antibody detects endogenous levels of total PMP22 protein. |
| General description: | Peripheral myelin protein 22 (PMP22), also called as growth arrest-specific protein 3 (GAS-3), is a tetraspan glycoprotein, encoded by the gene mapped to human chromosome 17p12–13. PMP22 is highly expressed in myelin-forming Schwann cells of peripheral nerves. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human PMP22. Immunogen Range: 111-160 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |