Anti-KCNT1 antibody produced in rabbit
SIGMA/SAB4502518 - affinity isolated antibody
Synonym: KCa4.1; Potassium channel subfamily T member 1
Product Type: Chemical
Immunohistochemistry Anti-KCNT1: Cat. No. SAB4502518: Immunohistochemistry analysis of paraffin-embedded human brain tissue using Anti-KCNT1 antibody. Cells on the left were treated with the Anti-KCNT1 antibody. Cells on the right (negative control) were treated with both Anti-KCNT1 antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 138 kDa |
| NCBI accession no. | Q5JUK3   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:10000 |
| immunohistochemistry: 1:50-1:100 | |
| UniProt accession no. | Q5JUK3 |
| Biochem/physiol Actions: | Mutations in KCNT1 (potassium sodium-activated channel subfamily T member 1) is observed in different epileptic disorders including epileptic encephalopathy, nocturnal frontal lobe epilepsy and malignant migrating partial seizures in infancy. KCNT1 is associated with neural oscillation and general learning disability. It also controls pain sensation. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
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| General description: | Anti-KCNT1 antibody detects endogenous levels of total KCNT1 protein. |
| General description: | The KCNT1 (potassium sodium-activated channel subfamily T member 1) gene is mapped to human chromosome 9q34.3. It is widely expressed in the brain, heart and dorsal root ganglia and well distributed in the nervous system. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human KCNT1. Immunogen Range: 1019-1068 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |