Anti-Retinoic Acid Receptor β, C-Terminal antibody produced in rabbit
SIGMA/SAB4502581 - affinity isolated antibody
Synonym: HBV-activated protein; RAR-β; RAR-ε; nuclear receptor 1B2; retinoic acid receptor β
MDL Number: MFCD00802879
Product Type: Chemical
Immunohistochemistry Anti-Retinoic Acid Receptor β: Cat. No. SAB4502581: Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Anti-Retinoic Acid Receptor β antibody. Cells on the left were treated with the Anti-Retinoic Acid Receptor β antibody. Cells on the right (negative control) were treated with both Anti-Retinoic Acid Receptor β antibody and the synthesized immunogen peptide.
Western Blotting Anti-Retinoic Acid Receptor β: Cat. No. SAB4502581: Immunoblotting analysis of extracts from HepG2 cells, using Anti-Retinoic Acid Receptor β antibody. The lane on the left was treated with the Anti-Retinoic Acid Receptor β antibody. The lane on the right (negative control) was treated with both Anti-Retinoic Acid Receptor β antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 50 kDa |
| NCBI accession no. | P10826   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:20000 |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P10826 |
| Biochem/physiol Actions: | Retinoic Acid Receptor β (RARB) interacts with its ligand retinoic acid (RA) and retinoid and plays a vital role in normal lung development. It is also involved in growth regulation of mammary epithelial cells. RARB acts as a tumor suppressor protein in various types of cancers, including thyroid carcinomas. Mutation in the gene is associated with the development of anophthalmia and/or microphthalmia and diaphragmatic hernia. RARβ gene inactivation caused by RARβ methylation contributes to the pathogenesis of non-small cell lung cancer (NSCLC) and acts as a potential biomarker, risk factor and therapeutic target for NSLC. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-Retinoic Acid Receptor β Antibody detects endogenous levels of total Retinoic Acid Receptor β protein. |
| General description: | Retinoic Acid Receptor β (RARB) is encoded by the gene mapped to human chromosome 3p24.2-p25. The encoded protein belongs to the nuclear receptor superfamily. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human Retinoic Acid Receptor beta. Immunogen Range: 331-380 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |