Anti-p70 S6 Kinase antibody produced in rabbit
SIGMA/SAB4502683 - affinity isolated antibody
Synonym: 70 kDa ribosomal protein S6 kinase 1; Ribosomal protein S6 kinase I; S6K; S6K1; p70 S6 kinase α
MDL Number: MFCD01092452
Product Type: Chemical
Immunohistochemistry Anti-p70 S6 Kinase: Cat. No. SAB4502683: Immunohistochemistry analysis of paraffin-embedded human brain tissue using Anti-p70 S6 Kinase antibody. Cells on the left were treated with the Anti-p70 S6 Kinase antibody. Cells on the right (negative control) were treated with both Anti-p70 S6 Kinase antibody and the synthesized immunogen peptide.
Immunofluorescence Anti-p70 S6 Kinase: Cat. No. SAB4502683: Immunofluorescence of HeLa cells using Anti-p70 S6 Kinase antibody. Cells on the left were treated with the Anti-p70 S6 Kinase antibody. Cells on the right (negative control) were treated with both Anti-p70 S6 Kinase antibody and the synthesized immunogen peptide.
Western Blotting Anti-p70 S6 Kinase: Cat. No. SAB4502683: Immunoblotting analysis of extracts from Jurkat cells, using Anti-p70 S6 Kinase antibody. The lane on the left was treated with the Anti-p70 S6 Kinase antibody. The lane on the right (negative control) was treated with both Anti-p70 S6 Kinase antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 59 kDa |
| NCBI accession no. | P23443   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:40000 |
| immunofluorescence: 1:100-1:500 | |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P23443 |
| Application: | Anti-p70 S6 Kinase antibody produced in rabbit has been used in western blotting (1:1000). |
| Biochem/physiol Actions: | Ribosomal protein S6 kinase, 70kDa, polypeptide 1 (RPS6KB1) undergoes acetylation, phosphorylation, and ubiquitination. It is involved in a variety of functions including glucose homeostasis, cell survival, and proliferation. RPS6KB1 also participates in cell structure and organization. It is implicated in ovarian cancer progression, muscle hypertrophy, aging, immunity, and memory. RPS6KB1 also regulates the replication and transcription of mumps virus (MuV). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Ribosomal protein S6 kinase, 70kDa, polypeptide 1 (RPS6KB1) belongs to the AGC kinase subfamily and comprises a catalytic domain, a linker region, and a putative autoinhibitory domain, in addition to the N-terminal and C-terminal domain. The RPS6KB1 gene is located on human chromosome 17q23.1. It exists in multiple isoforms due to alternative splice events. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human p70 S6 Kinase. Immunogen Range: 195-244 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |