Anti-SODIUM CHANNEL-PAN antibody produced in rabbit
SIGMA/SAB4502713 - affinity isolated antibody
Synonym: CIN5; HH1; SCN5A; Sodium channel protein; cardiac muscle α-subunit
MDL Number: MFCD02097413
Product Type: Chemical
Immunohistochemistry Anti-SODIUM CHANNEL-PAN: Cat. No. SAB4502713: Immunohistochemistry analysis of paraffin-embedded human heart tissue using Anti-SODIUM CHANNEL-PAN antibody. Cells on the left were treated with the Anti-SODIUM CHANNEL-PAN antibody. Cells on the right (negative control) were treated with both Anti-SODIUM CHANNEL-PAN antibody and the synthesized immunogen peptide.
Western Blotting Anti-SODIUM CHANNEL-PAN: Cat. No. SAB4502713: Immunoblotting analysis of extracts from HuvEc cells, using Anti-SODIUM CHANNEL-PAN antibody. The lane on the left was treated with the Anti-SODIUM CHANNEL-PAN antibody. The lane on the right (negative control) was treated with both Anti-SODIUM CHANNEL-PAN antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 227 kDa |
| NCBI accession no. | P35498   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, human, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:20000 |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | Q99250 |
| Biochem/physiol Actions: | SCN5A (sodium channel protein type 5 subunit α) is associated with the regulation of myocardial excitability as it conducts cardiac depolarization via inward Na+ current. Mutation in SCN5A causes retarded cardiac repolarization resulting in congenital long QT syndrome and also causes Brugada syndrome due to loss of gene function. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
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| General description: | Anti-SODIUM CHANNEL-PAN Antibody detects endogenous levels of total SODIUM CHANNEL-PAN protein. |
| General description: | The SCN5A (sodium channel protein type 5 subunit α) gene is mapped to human chromosome 3p22.2. The encoded protein is known to be localized to cardiac cells. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human Sodium Channel. Immunogen Range: 1466-1515 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |