Anti-GLUT1 antibody produced in rabbit
SIGMA/SAB4502803 - affinity isolated antibody
Synonym: GLUT-1; Glucose transporter type 1 erythrocyte/brain; HepG2 glucose transporter; SLC2A1; Solute carrier family 2 facilitated glucose transporter member 1
Product Type: Chemical
Immunohistochemistry Anti-GLUT1: Cat. No. SAB4502803: Immunohistochemistry analysis of paraffin-embedded human brain tissue using Anti-GLUT1 antibody. Cells on the left were treated with the Anti-GLUT1 antibody. Cells on the right (negative control) were treated with both Anti-GLUT1 antibody and the synthesized immunogen peptide.
Western Blotting Anti-GLUT1: Cat. No. SAB4502803: Immunoblotting analysis of extracts from Jurkat cells, using Anti-GLUT1 antibody. The lane on the left was treated with the Anti-GLUT1 antibody. The lane on the right (negative control) was treated with both Anti-GLUT1 antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 54 kDa |
| NCBI accession no. | P11166   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, human, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:40000 |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P11166 |
| Application: | Anti-GLUT1 antibody produced in rabbit has been used • for protein extraction • in western blotting • for immunohistochemistry |
| Application: | Anti-GLUT1, C-Terminal antibody is suitable for use in western blot and immunohistochemistry. |
| Biochem/physiol Actions: | GLUT1 (Glucose transporter type 1) functions as a receptor for human T-cell leukemia virus (HTLV) I and II. It plays a key role in HTLV-envelope mediated infection. GLUT1 is associated with paroxysmal exertion-induced dyskinesia. Glut1 may regulate cerebral microvasculature, proliferation of endothelial cells and the development of junctional complexes of the BBB (blood-brain barrier). It transports glucose across the BBB. |
| Biochem/physiol Actions: | GLUT1 is a membrane protein that regulates the facilitative transport of glucose across the cells. Mutations in the gene encoding GLUT1 have been linked to epilepsy and diabetic nephropathy . Increased expression of GLUT1 has been associated with tumor differentiation in breast and endometrial cancers, whereas decreased GLUT1 function causes GLUT1 deficiency syndrome . Anti-GLUT1, C-Terminal antibody can be used to detect endogenous levels of total GLUT1 protein. The antibody specifically reacts with GLUT1 in mice, rats and humans. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-GLUT1 Antibody detects endogenous levels of total GLUT1 protein. |
| General description: | GLUT1 (Glucose transporter type 1) gene is located on human chromosome 1p34.2. It is expressed in cerebral endothelial cells. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human GLUT1. Immunogen Range: 441-490 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |