Anti-Synuclein-α antibody produced in rabbit
SIGMA/SAB4502829 - affinity isolated antibody
Synonym: α-synuclein; NACP; Non-A β component of AD amyloid; Non-A4 component of amyloid precursor; SNCA
MDL Number: MFCD02095740
Product Type: Chemical
Western Blotting Anti-Synuclein-α: Cat. No. SAB4502829: Immunoblotting analysis of extracts from rat brain/mouse brain cells, using Anti-Synuclein-α antibody. The lane on the left was treated with the Anti-Synuclein-α antibody. The lane on the right (negative control) was treated with both Anti-Synuclein-α antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 14 kDa |
| NCBI accession no. | P37840   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, rat, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:40000 |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P37840 |
| Biochem/physiol Actions: | Accumulation of α-synuclein in oligodendrocytes results in the loss of myelin and causes neurodegeneration, leading to multiple system atrophy. Synuclein-α is known to induce oligodendrocyte maturation. The encoded protein is considered to be an important aggregate of Lewy bodies, contributing to the pathogenesis of Parkinson disease. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
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| General description: | Anti-Synuclein-α antibody detects endogenous levels of total Synuclein-α protein. |
| General description: | The SNCA (synuclein α) gene is mapped to human chromosome 4q22.1. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human Synuclein-alpha. Immunogen Range: 86-135 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |