Anti-Synaptophysin antibody produced in rabbit
SIGMA/SAB4502906 - affinity isolated antibody
Synonym: major synaptic vesicle protein p38; synaptophysin
MDL Number: MFCD00164741
Product Type: Chemical
Immunocytochemistry-immunoflourescence JOURNAL CITATION: SAP97 Binding Partner CRIPT Promotes Dendrite Growth In Vitro and In Vivo. By: Zhang, L., Jablonski, A. M., et al. in Eneuro, 2017. PubMed ID: 29218323 Image collected and cropped by CiteAb from the following publication, (http://eneuro.sfn.org/lookup/doi/10.1523/ENEURO.0175-17.2017), provided under a CC-BY license. Image might reflect a new usage that is not reflected in claims on product description or independently verified by Merck KGaA, Darmstadt, Germany. For Research Use Only. Not for use in diagnostic procedures.
Immunohistochemistry Anti-Synaptophysin: Cat. No. SAB4502906: Immunohistochemistry analysis of paraffin-embedded human brain tissue using Anti-Synaptophysin antibody. Cells on the left were treated with the Anti-Synaptophysin antibody. Cells on the right (negative control) were treated with both Anti-Synaptophysin antibody and the synthesized immunogen peptide.
Western Blotting Anti-Synaptophysin: Cat. No. SAB4502906: Immunoblotting analysis of extracts from LOVO cells, using Anti-Synaptophysin antibody. The lane on the left was treated with the Anti-Synaptophysin antibody. The lane on the right (negative control) was treated with both Anti-Synaptophysin antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 33 kDa |
| NCBI accession no. | P08247   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, rat, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:10000 |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P08247 |
| Application: | Anti-synaptophysin antibody is suitable for use in immunohistochemistry and western blot. |
| Application: | Anti-Synaptophysin antibody produced in rabbit has been used in: • immunocytochemistry • western blotting • immunohistochemistry |
| Biochem/physiol Actions: | Synaptophysin (SYP) modulates neurotransmitter release and synaptic plasticity. It maintains biogenesis and recycling of synaptic vesicles. SYP functions as a marker for neuroendocrine tumors. It is used as a potent marker for neuroendocrine prostate cancer (NEPC). Mutations in this gene is associated with X-linked intellectual disability. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Synaptophysin (SYP) is an integral membrane protein of synaptic vesicles. It is expressed in cortical synaptic terminals, during neurogenesis. The gene is located on human chromosome Xp11.23. |
| General description: | Synaptophysin is an integral membrane glycoprotein that is localized in presynaptic vesicles of nerve cells. This protein may regulate exocytosis and the formation of synaptic vesicles . Synaptophysin is encoded by the SYP gene and genetic alterations in SYP can lead to mental retardation . Anti-synaptophysin antibody specifically detects endogenous levels of total synaptophysin protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human Synaptophysin. Immunogen Range: 101-150 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |