Anti-Telomerase antibody produced in rabbit
SIGMA/SAB4502945 - affinity isolated antibody
Synonym: EST2; HEST2; TCS1; Telomerase catalytic subunit; Telomerase reverse transcriptase
Product Type: Chemical
Western Blotting Anti-Telomerase: Cat. No. SAB4502945: Immunoblotting analysis of extracts from Jurkat cells, using Anti-Telomerase antibody. The lane on the left was treated with the Anti-Telomerase antibody. The lane on the right (negative control) was treated with both Anti-Telomerase antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 126 kDa |
| NCBI accession no. | O14746   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:1000 |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | O14746 |
| Biochem/physiol Actions: | TERT (telomerase reverse transcriptase) catalyzes the de novo synthesis of telomere and results in cellular immortalization to maintain chromosomal stability. Mutations in TERT causes different types of malignancies such as gliomas, gastric cancer, and anaplastic thyroid cancer. Therefore, TERT serves as an early prognostic biomarker. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-Telomerase Antibody detects endogenous levels of total Telomerase protein. |
| General description: | The TERT (telomerase reverse transcriptase) gene is mapped to human chromosome 5p15.33 and encodes for a ribonucleoprotein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human Telomerase. Immunogen Range: 796-845 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |