Anti-TGF β Receptor I antibody produced in rabbit
SIGMA/SAB4502958 - affinity isolated antibody
Synonym: ADRB2; ALK-5; Activin receptor-like kinase 5; ESK2; SKR4
Product Type: Chemical
Western Blotting JOURNAL CITATION: FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway. By: Li, J., Shi, S., et al. in Cell Death Dis, 2017. PubMed ID: 28771231 Image collected and cropped by CiteAb from the following publication, (http://www.nature.com/articles/cddis2017353), provided under a CC-BY license. Image might reflect a new usage that is not reflected in claims on product description or independently verified by Merck KGaA, Darmstadt, Germany. For Research Use Only. Not for use in diagnostic procedures.
Western Blotting JOURNAL CITATION: FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway. By: Li, J., Shi, S., et al. in Cell Death Dis, 2017. PubMed ID: 28771231 Image collected and cropped by CiteAb from the following publication, (http://www.nature.com/articles/cddis2017353), provided under a CC-BY license. Image might reflect a new usage that is not reflected in claims on product description or independently verified by Merck KGaA, Darmstadt, Germany. For Research Use Only. Not for use in diagnostic procedures.
Immunofluorescence Anti-TGF β Receptor I: Cat. No. SAB4502958: Immunofluorescence of HeLa cells using Anti-TGF β Receptor I antibody. Cells on the left were treated with the Anti-TGF β Receptor I antibody. Cells on the right (negative control) were treated with both Anti-TGF β Receptor I antibody and the synthesized immunogen peptide.
Western Blotting Anti-TGF β Receptor I: Cat. No. SAB4502958: Immunoblotting analysis of extracts from HepG2/COLO cells, using Anti-TGF β Receptor I antibody. The lane on the left was treated with the Anti-TGF β Receptor I antibody. The lane on the right (negative control) was treated with both Anti-TGF β Receptor I antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 55 kDa |
| NCBI accession no. | P36897   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, human, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:10000 |
| immunofluorescence: 1:100-1:500 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P36897 |
| Application: | Anti-TGF β Receptor I antibody produced in rabbit has been used for: • Immunohistochemistry • Western blotting • Immunofluroscence |
| Biochem/physiol Actions: | Transforming growth factor β receptor-1 (TGF-β R1) plays an essential role in carbon nanotube-induced fibrogenesis by enhancing collagen production in lung fibroblasts. TβR-dependent signals plays a crucial role in cell growth and differentiation, and polymorphism or mutation of TGF-β R1 leads to head and neck cancer. Activin receptor-like kinase 5 (ALK5) or TGF-β R1 promotes the phosphorylation of small mothers against decapentaplegic (Smad) 2 and Smad3. Activated ALK5 inhibits migration and proliferation of endothelial cells (ECs). ALK1 acts as an antagonist for ALK5/Smad signaling. Mutation of TGF-β R1 can also cause autosomal dominant skin cancer called multiple self-healing squamous epithelioma (MSSE) or Ferguson-Smith disease (FSD). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-TGF β Receptor I Antibody detects endogenous levels of total TGF β Receptor I protein. |
| General description: | Transforming growth factor β receptor-1 (TGF-β R1), also known as activin receptor-like kinase 5 (ALK5) receptor, is encoded by the gene mapped to human chromosome 9q22.3. It is widely expressed in human tissues. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human TGF beta Receptor I. Immunogen Range: 131-180 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |