Anti-C1QB, C-Terminal antibody produced in rabbit
SIGMA/SAB4502986 - affinity isolated antibody
Synonym: Complement C1q subcomponent subunit B
Product Type: Chemical
Immunofluorescence Anti-C1QB: Cat. No. SAB4502986: Immunofluorescence of A549 cells using Anti-C1QB antibody. Cells on the left were treated with the Anti-C1QB antibody. Cells on the right (negative control) were treated with both Anti-C1QB antibody and the synthesized immunogen peptide.
Western Blotting Anti-C1QB: Cat. No. SAB4502986: Immunoblotting analysis of extracts from Jurkat cells, using Anti-C1QB antibody. The lane on the left was treated with the Anti-C1QB antibody. The lane on the right (negative control) was treated with both Anti-C1QB antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 26 kDa |
| NCBI accession no. | P02746   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:40000 |
| immunofluorescence: 1:100-1:500 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P02746 |
| Biochem/physiol Actions: | The protein encoded by C1QB (complement C1q B chain) gene is involved in synapse formation and offers neuroprotection in the central nervous system. In response to a number of immune and nonimmune ligands, C1q protein activates proteases C1r and C1s in order to trigger classical complement pathway. C1q protein is regarded as a major component of the humoral innate immune defense. C1q carries out opsonophagocytosis, inflammation, and cytolysis to eliminate pathogenic microorganism and harmful apoptotic cells. Mutations in the gene causes systemic lupus erythematosus. Variation in the gene is also linked to rheumatoid schizophrenia, arthritis, amyloidotic polyneuropathy, metastasis of cancer. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-C1QB Antibody detects endogenous levels of total C1QB protein. |
| General description: | The C1QB (complement C1q B chain) gene is mapped to human chromosome 1p36.12 and codes for the subcomponent of C1q protein, which is part of C1 complex of the classical pathway. The encoded protein is predominantly expressed in neurons and glia. It is localized to the growing synapses. The encoded protein is a hexameric molecule consisting of three distinct types of 18 polypeptide chains. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human C1QB. Immunogen Range: 161-210 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |