Anti-TNF Receptor I antibody produced in rabbit
SIGMA/SAB4502988 - affinity isolated antibody
Synonym: CD120a; TBPI; TNF-RI; p55; p60
Product Type: Chemical
Immunohistochemistry Anti-TNF Receptor I: Cat. No. SAB4502988: Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Anti-TNF Receptor I antibody. Cells on the left were treated with the Anti-TNF Receptor I antibody. Cells on the right (negative control) were treated with both Anti-TNF Receptor I antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 50 kDa |
| NCBI accession no. | P19438   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:20000 |
| immunohistochemistry: 1:50-1:100 | |
| UniProt accession no. | P19438 |
| Application: | Anti-TNF Receptor I antibody produced in rabbit has been used in immunostaining at a dilution of 1:200. |
| Biochem/physiol Actions: | Tumor necrosis factor receptor 1 (TNFR1) is crucial for TNF for eliciting proinflammatory functions. Through its dead domain motif, TNFR1 interacts with the TNF receptor-associated death domain protein (TRADD). TNFR1 regulates cytotoxic signaling pathways. Blockage of TNFR1 in mouse model harboring respiratory syncytial virus (RSV) infection results in enhanced bronchoconstriction. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Tumor necrosis factor receptor 1 (TNFR1) belongs to the TNFR superfamily and is ubiquitously expressed. It comprises an extracellular domain with a cysteine-rich motif, a transmembrane segment, and an intracellular domain with a “death domain” motif. The TNFR1 gene is mapped to human chromosome 12p13.31. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human TNF Receptor I. Immunogen Range: 381-430 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |