Anti-Vitamin D Receptor antibody produced in rabbit
SIGMA/SAB4503071 - affinity isolated antibody
Synonym: 1,25-
MDL Number: MFCD00802899
Product Type: Chemical
Immunohistochemistry Anti-Vitamin D Receptor: Cat. No. SAB4503071: Immunohistochemistry analysis of paraffin-embedded human thyroid gland tissue using Anti-Vitamin D Receptor antibody. Cells on the left were treated with the Anti-Vitamin D Receptor antibody. Cells on the right (negative control) were treated with both Anti-Vitamin D Receptor antibody and the synthesized immunogen peptide.
Immunofluorescence Anti-Vitamin D Receptor: Cat. No. SAB4503071: Immunofluorescence of HeLa cells using Anti-Vitamin D Receptor antibody. Cells on the left were treated with the Anti-Vitamin D Receptor antibody. Cells on the right (negative control) were treated with both Anti-Vitamin D Receptor antibody and the synthesized immunogen peptide.
Western Blotting Anti-Vitamin D Receptor: Cat. No. SAB4503071: Immunoblotting analysis of extracts from MCF-7 cells, using Anti-Vitamin D Receptor antibody. The lane on the left was treated with the Anti-Vitamin D Receptor antibody. The lane on the right (negative control) was treated with both Anti-Vitamin D Receptor antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 48 kDa |
| NCBI accession no. | P11473   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:10000 |
| immunofluorescence: 1:100-1:500 | |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P11473 |
| Application: | Anti-Vitamin D Receptor antibody produced in rabbit has been used in western blotting and immunofluorescence staining (1:200) (1:100). |
| Biochem/physiol Actions: | Vitamin D receptor (VDR) protein modulates genes associated with inflammation, chronic diseases, oxidative damage, and the metabolism of bone. VDR gene is involved in the susceptibility of type 2 diabetes mellitus (T2DM). The nuclear receptor encoded by the VDR gene possesses pluripotent effects. It is capable of specifically binding the elements of DNA response when bound to the ligand. VDR acts as a receptor for 1,25 dihydroxyvitamin D3 (1,25(OH)2 D3). It facilitates the biological activities of vitamin D. Inadequacy of vitamin D is a risk factor for Alzheimer′s disease (AD). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-Vitamin D Receptor Antibody detects endogenous levels of total Vitamin D Receptor protein. |
| General description: | Vitamin D receptor (VDR) gene codes for a nuclear receptor. It is expressed at a high level in the hypothalamus and the large neurons of the substantia nigra in the brain. VDR gene comprises 14 exons and 6 untranslated exons with alternative splicing sites. It is mapped to human chromosome 12q13.1. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human Vitamin D Receptor. Immunogen Range: 181-230 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |