Anti-FZD3 antibody produced in rabbit
SIGMA/SAB4503170 - affinity isolated antibody
Synonym: FZD3; Frizzled-3; Fz-3; hFz3
MDL Number: MFCD06798445
Product Type: Chemical
Immunofluorescence Anti-FZD3: Cat. No. SAB4503170: Immunofluorescence of COS7 cells using Anti-FZD3 antibody. Cells on the left were treated with the Anti-FZD3 antibody. Cells on the right (negative control) were treated with both Anti-FZD3 antibody and the synthesized immunogen peptide.
Western Blotting Anti-FZD3: Cat. No. SAB4503170: Immunoblotting analysis of extracts from A549/RAW264.7 cells, using Anti-FZD3 antibody. The lane on the left was treated with the Anti-FZD3 antibody. The lane on the right (negative control) was treated with both Anti-FZD3 antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 76 kDa |
| NCBI accession no. | Q9NPG1   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:1000 |
| immunofluorescence: 1:100-1:500 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | Q9NPG1 |
| Application: | Anti-FZD3 antibody produced in rabbit has been used in immunohistochemistry. |
| Biochem/physiol Actions: | Mutation in FZD3 (frizzled class receptor 3) gene might account for Hirschsprung disease, a birth defect lacking the intrinsic ganglion cells of the lower intestine. FZD3 regulates the growth of longitudinal axon tracts in the central nervous system. FZD3 mediates the dynamics of axon within the enteric, sympathetic and peripheral nervous systems. FZD3 regulates planar cell polarity. Abnomal FZD3 gene methylation causes chromatin structure modifications, associated with congenital hydrocephalus. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-FZD3 Antibody detects endogenous levels of total FZD3 protein. |
| General description: | The FZD3 (frizzled class receptor 3) gene is mapped to human chromosome 8p21.1. It codes for a receptor with seven-transmembrane domain and is expressed in human melanocytes. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human FZD3. Immunogen Range: 141-190 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |