Anti-Collagen XVIII α1 antibody produced in rabbit
SIGMA/SAB4503213 - affinity isolated antibody
Synonym: COIA1; Collagen α-1(XVIII) chain; Endostatin
Product Type: Chemical
Immunohistochemistry Collagen XVIII alpha1 Antibody: Cat. No. SAB4503213: Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using Collagen XVIII alpha1 Antibody. The picture on the right is treated with the synthesized peptide.
Immunofluorescence Anti-Collagen XVIII α1: Cat. No. SAB4503213: Immunofluorescence of A549 cells using Anti-Collagen XVIII α1 antibody. Cells on the left were treated with the Anti-Collagen XVIII α1 antibody. Cells on the right (negative control) were treated with both Anti-Collagen XVIII α1 antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 178 kDa |
| NCBI accession no. | P39060   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:5000 |
| immunofluorescence: 1:100-1:500 | |
| immunohistochemistry: 1:50-1:100 | |
| UniProt accession no. | P39060 |
| Biochem/physiol Actions: | Endostatin inhibits the proliferation and migration of endothelial cells. It blocks apoptosis of cells and G1 to S phase transition in the cell cycle. It inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Mutations in this gene lead to Knobloch Syndrome (KS), a rare autosomal recessive disorder. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Endostatin is a naturally occurring 20kDa polypeptide derived from the C-terminal portion of type XVIII collagen. It functions as an anti-angiogenic cytokine that is expressed in various organs with the highest levels in liver, lung and kidney. The gene encoding it is localized on human chromosome 21q22.3. Anti-Collagen XVIII α1 Antibody detects endogenous levels of total Collagen XVIII α1 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human Collagen XVIII alpha1. Immunogen Range: 801-850 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |