Anti-CAMK2 antibody produced in rabbit
SIGMA/SAB4503250 - affinity isolated antibody
Synonym: CAMK2A; CaM-kinase II α chain; CaMK-II α subunit; CaMKII-α; Calcium/
Product Type: Chemical
Immunohistochemistry CaMK2 alpha/delta (Ab-286) Antibody: Cat. No. SAB4503250: Immunohistochemistry analysis of paraffin-embedded human brain tissue, using CaMK2 alpha/delta (Ab-286) Antibody. The picture on the right is treated with the synthesized peptide.
Immunofluorescence Anti-CAMK2: Cat. No. SAB4503250: Immunofluorescence of MCF7 cells using Anti-CAMK2 antibody. Cells on the left were treated with the Anti-CAMK2 antibody. Cells on the right (negative control) were treated with both Anti-CAMK2 antibody and the synthesized immunogen peptide.
Western Blotting Anti-CAMK2: Cat. No. SAB4503250: Immunoblotting analysis of extracts from NIH-3T3/K562 cells, using Anti-CAMK2 antibody. The lane on the left was treated with the Anti-CAMK2 antibody. The lane on the right (negative control) was treated with both Anti-CAMK2 antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 54 kDa |
| NCBI accession no. | Q9UQM7   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:10000 |
| immunofluorescence: 1:100-1:500 | |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | Q13557 |
| Biochem/physiol Actions: | Calcium/calmodulin dependent protein kinase II α (CAMK2) is essential for long-term potentiation (LTP) and spatial memory. It regulates synaptic plasticity. Dysfunction in this gene is associated with schizophrenia, epilepsy and autism spectrum disorders. |
| Biochem/physiol Actions: | Calmodulin dependent protein kinase II complex δ (CAMK2D) modulates the functions of ion channels and Ca2+ handling proteins. It also regulates the phosphorylation and acetylation of histones. It has been shown to be overexpressed in the myocardium of diabetic patients. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-CAMK2 Antibody detects endogenous levels of total CAMK2 protein. |
| General description: | Calcium/calmodulin dependent protein kinase II α (CAMK2) is a calcium-activated serine/threonine kinase. The gene is located on human chromosome 5q32. CAMK2 is mainly expressed in the central nervous system. It consists of a kinase domain, a regulatory domain and an association domain. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human CaMK2 alpha/delta. Immunogen Range: 256-305 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |