Anti-Calcium Sensing Receptor antibody produced in rabbit
SIGMA/SAB4503369 - affinity isolated antibody
Synonym: CASR; CaSR; Extracellular calcium-sensing receptor; PCaR1; Parathyroid Cell calcium-sensing receptor
MDL Number: MFCD02262635
Product Type: Chemical
Immunohistochemistry Anti-Calcium Sensing Receptor: Cat. No. SAB4503369: Immunohistochemistry analysis of paraffin-embedded human brain tissue using Anti-Calcium Sensing Receptor antibody. Cells on the left were treated with the Anti-Calcium Sensing Receptor antibody. Cells on the right (negative control) were treated with both Anti-Calcium Sensing Receptor antibody and the synthesized immunogen peptide.
Western Blotting Anti-Calcium Sensing Receptor: Cat. No. SAB4503369: Immunoblotting analysis of extracts from LOVO cells, using Anti-Calcium Sensing Receptor antibody. The lane on the left was treated with the Anti-Calcium Sensing Receptor antibody. The lane on the right (negative control) was treated with both Anti-Calcium Sensing Receptor antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 120 kDa |
| NCBI accession no. | P41180   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:5000 |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P41180 |
| Biochem/physiol Actions: | Calcium sensing receptor (CASR) modulates the activities of cells according to the extracellular calcium concentration. It also plays a major role in controlling parathyroid hormone (PTH) secretion. CASR has a vital role in signal transduction pathways in various tissues like parathyroid gland, kidney, gastrointestinal tract, placenta, pancreas and brain. Mutation in the gene is linked with autosomal dominant hypocalcemic, hypercalciuria and Bartter syndrome. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-Calcium Sensing Receptor Antibody detects endogenous levels of total Calcium Sensing Receptor protein. |
| General description: | The calcium sensing receptor (CASR) is a 1078 amino acid protein. It has 11 exons and is located on human chromosome 3q13.33-q21.1. CASR belongs to the C family of G protein–coupled receptors. It is located in the parathyroid gland and the thick ascending limb of the Henle loop. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human Calcium Sensing Receptor. Immunogen Range: 854-903 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |