Anti-LAT3 antibody produced in rabbit
SIGMA/SAB4503399 - affinity isolated antibody
Synonym: L-type amino acid transporter 3; Prostate cancer overexpressed gene 1 protein; SLC43A1; Solute carrier family 43 member 1
Product Type: Chemical
Western Blotting Anti-LAT3: Cat. No. SAB4503399: Immunoblotting analysis of extracts from A549/Jurkat cells, using Anti-LAT3 antibody. The lane on the left was treated with the Anti-LAT3 antibody. The lane on the right (negative control) was treated with both Anti-LAT3 antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 61 kDa |
| NCBI accession no. | O75387   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:20000 |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | O75387 |
| Biochem/physiol Actions: | LAT3/SLC43A1 (solute carrier family 43 member 1) is essential for the growth and activities of podocytes. In prostate cancer cell lines, silencing the expression of LAT3 stops the initiation of mTORC1 (mammalian target of rapamycin complex 1) pathway activation, cell growth and cell cycle both in vitro and in vivo. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-LAT3 Antibody detects endogenous levels of total LAT3 protein. |
| General description: | LAT3/SLC43A1 (solute carrier family 43 member 1), a Na+-independent neutral L-amino acid transporter, is mapped to human chromosome 11q12.1. It is expressed in liver, skeletal muscle and pancreas. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human LAT3. Immunogen Range: 231-280 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |