Anti-phospho-STAT2 (pTyr690) antibody produced in rabbit
SIGMA/SAB4503836 - affinity isolated antibody
Synonym: Anti-IMD44; Anti-ISGF-3; Anti-P113; Anti-PTORCH3; Anti-STAT113
Product Type: Chemical
Immunohistochemistry Anti-phoshpho-STAT2 (pTyr690): Cat. No. SAB4503836: Immunohistochemistry analysis of paraffin-embedded Human colon carcinoma.
Immunohistochemistry Anti-phoshpho-STAT2 (pTyr690): Cat. No. SAB4503836: Immunohistochemistry analysis of paraffin-embedded Human Non-Hodgkin′s lymphoma.
Immunohistochemistry Anti-phoshpho-STAT2 (pTyr690): Cat. No. SAB4503836: Immunohistochemistry analysis of paraffin-embedded Human stomach carcinoma.
Immunohistochemistry Anti-phoshpho-STAT2 (pTyr690): Cat. No. SAB4503836: Immunohistochemistry analysis of paraffin-embedded Human tonsil.
Western Blotting Anti-phoshpho-STAT2 (pTyr690): Cat. No. SAB4503836: Western blot analysis of extracts from HeLa cells treated with 2500 U/mL IFN for 30 minutes.
ELISA Anti-phoshpho-STAT2 (pTyr690): Cat. No. SAB4503836: ELISA for Immunogen Phosphope(pTide (left) and Non-Phosphope(pTide (right).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 97 kDa |
| NCBI accession no. | P52630   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr690) |
| technique(s) | ELISA: 1:20000 |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P52630 |
| Application: | Anti-phospho-STAT2 (pTyr690) antibody produced in rabbit has been used in western blotting, immunofluorescence staining and flow cytometric staining. |
| Application: | Anti-phospho-STAT2 (pTyr690) antibody produced in rabbit has been used: • for western blotting • for immunofluorescence staining • for flow cytometric staining |
| Biochem/physiol Actions: | Signal transducer and activator of transcription 2 (STAT2) is activated by interferon-1 (IFN-I) and IFN-III. It aids protein-protein interactions and is essential for binding IRF9. STAT2 is required for the nuclear export of STAT2-IFN regulatory factor 9 (IRF9) and IFN-stimulated gene factor 3 (ISGF3). It plays a vital role in interactions with STAT1. |
| Biochem/physiol Actions: | STAT2 (signal transducer and activator of transcription 2) participates in immunity. It plays a major role in interferon signaling pathways. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Signal transducer and activator of transcription 2 (STAT2) belongs to the STAT family. The gene is located on human chromosome 12q13.3. STAT2 consists of 24 exons and has a molecular weight of 113 kDa. It consists of N-terminal domain (N), coiled-coil domain (CC), DNA-binding domain (DBD), linker domain (L), Src homology 2 domain (SH2), tyrosine phosphorylation site (Y) and transcriptional activation domain (TAD). |
| General description: | STAT2 (signal transducer and activator of transcription 2) is mapped to human chromosome 12. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human STAT2 around the phosphorylation site of Tyr690. Immunogen Range: 656-705 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |