Anti-phospho-Arrestin 1 (pSer412) antibody produced in rabbit
SIGMA/SAB4503894 - affinity isolated antibody
Product Type: Chemical
Immunohistochemistry Anti-phoshpho-Arrestin 1 (pSer412): Cat. No. SAB4503894: Immunohistochemistry analysis of paraffin-embedded Human brain gliomas.
Immunohistochemistry Anti-phoshpho-Arrestin 1 (pSer412): Cat. No. SAB4503894: Immunohistochemistry analysis of paraffin-embedded Human colon carcinoma.
Immunohistochemistry Anti-phoshpho-Arrestin 1 (pSer412): Cat. No. SAB4503894: Immunohistochemistry analysis of paraffin-embedded Human ovary carcinoma.
Immunohistochemistry Anti-phoshpho-Arrestin 1 (pSer412): Cat. No. SAB4503894: Immunohistochemistry analysis of paraffin-embedded Human stomach carcinoma.
Western Blotting Anti-phoshpho-Arrestin 1 (pSer412): Cat. No. SAB4503894: Western blot analysis of extracts from COS-7 cells treated with 25 μM Etoposide for 60 minutes.
ELISA Anti-phoshpho-Arrestin 1 (pSer412): Cat. No. SAB4503894: ELISA for Immunogen Phosphope(pTide (left) and Non-Phosphope(pTide (right).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 47 kDa |
| NCBI accession no. | P49407   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, human, mouse |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer412) |
| technique(s) | ELISA: 1:1000 |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P49407 |
| Biochem/physiol Actions: | Arrestin 1 (ARRB1) participates in DNA damage accumulation and cell apoptosis. Deletion of ARRB1 blocks DDR (DNA damage response) pathway activation. During hypoxia, ARRB1 controls breast cancer cell survival with the help of HIF-1 transcription factor. This gene can act as a scaffold and an adaptor in receptor endocytosis and signal transduction. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Arrestin 1 (ARRB1) is also termed as β-arrestin-1. This is a cytoplasmic adaptor protein located on human chromosome 11q13. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human Arrestin 1 around the phosphorylation site of Ser412. Immunogen Range: 369-418 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |