Anti-phospho-IR (pTyr1355) antibody produced in rabbit
SIGMA/SAB4503924 - affinity isolated antibody
Product Type: Chemical
Immunohistochemistry Anti-phoshpho-IR (pTyr1355): Cat. No. SAB4503924: Immunohistochemistry analysis of paraffin-embedded Human colon carcinoma.
Immunohistochemistry Anti-phoshpho-IR (pTyr1355): Cat. No. SAB4503924: Immunohistochemistry analysis of paraffin-embedded Human Non-Hodgkin′s lymphoma.
Western Blotting Anti-phoshpho-IR (pTyr1355): Cat. No. SAB4503924: Western blot analysis of extracts from HEK 293 cells treated with Heat shock.
ELISA Anti-phoshpho-IR (pTyr1355): Cat. No. SAB4503924: ELISA for Immunogen Phosphope(pTide (left) and Non-Phosphope(pTide (right).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 156 kDa |
| NCBI accession no. | P06213   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, rat, human |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr1355) |
| technique(s) | ELISA: 1:10000 |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P06213 |
| Biochem/physiol Actions: | Insulin binds to its receptor (INSR) or to the structurally related insulin-like growth factor-I receptor (IGFIR) to control the development and apoptosis of cells. Aberrations in exon 17 of insulin receptor (INSR) gene result in PCOS (polycystic ovary syndrome). It plays a key role in insulin metabolism. Mutations in INSR results in insulin-resistant syndromes like leprechaunism (donohue syndrome), rabson–mendenhall syndrome and type A insulin resistance. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Insulin receptor (INSR) is located on human chromosome 19. It has 22 exons spanning 120 kilobases. The gene product of INSR has a leader sequence of 27 amino acids. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human IR around the phosphorylation site of Tyr1355. Immunogen Range: 1326-1375 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |