Anti-phospho-Survivin (pThr34) antibody produced in rabbit
SIGMA/SAB4503993 - affinity isolated antibody
Product Type: Chemical
Immunohistochemistry Anti-phoshpho-Survivin (pThr34): Cat. No. SAB4503993: Immunohistochemistry analysis of paraffin-embedded Human liver carcinoma.
Immunohistochemistry Anti-phoshpho-Survivin (pThr34): Cat. No. SAB4503993: Immunohistochemistry analysis of paraffin-embedded Human ovary carcinoma.
Western Blotting Anti-phoshpho-Survivin (pThr34): Cat. No. SAB4503993: Western blot analysis of extracts from HT29 cells treated with 100 μg/mL EGF for 30 minutes.
ELISA Anti-phoshpho-Survivin (pThr34): Cat. No. SAB4503993: ELISA for Immunogen Phosphope(pTide (left) and Non-Phosphope(pTide (right).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 16 kDa |
| NCBI accession no. | O15392   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, human, mouse |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pThr34) |
| technique(s) | ELISA: 1:1000 |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | O15392 |
| Biochem/physiol Actions: | Survivin/BIRC5 (baculoviral inhibitor of apoptosis repeat-containing 5) plays a major role in ATL (adult T-cell leukemia/lymphoma) cell viability. It can block apoptosis and induce the multiplication of cell. BIRC5 also plays a major role in the development of cancer. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Survivin is also termed as BIRC5 (baculoviral inhibitor of apoptosis repeat-containing 5). It is a multifunctional protein. It belongs to the inhibitor of apoptosis protein (IAP) family. BIRC5 is expressed in fetal tissues and several human malignancies like melanoma. Survivin is located on human chromosome 17q25. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human Survivin around the phosphorylation site of Thr34. Immunogen Range: 11-60 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |