Anti-phospho-TIE2 (pTyr1108) antibody produced in rabbit
SIGMA/SAB4503999 - affinity isolated antibody
Synonym: Anti-CD202B; Anti-GLC3E; Anti-TIE-2; Anti-VMCM; Anti-VMCM1
Product Type: Chemical
Immunohistochemistry Anti-phoshpho-TIE2 (pTyr1108): Cat. No. SAB4503999: Immunohistochemistry analysis of paraffin-embedded Human brain gliomas.
Immunohistochemistry Anti-phoshpho-TIE2 (pTyr1108): Cat. No. SAB4503999: Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma.
Immunohistochemistry Anti-phoshpho-TIE2 (pTyr1108): Cat. No. SAB4503999: Immunohistochemistry analysis of paraffin-embedded Human colon carcinoma.
Immunohistochemistry Anti-phoshpho-TIE2 (pTyr1108): Cat. No. SAB4503999: Immunohistochemistry analysis of paraffin-embedded Human kidney carcinoma.
Immunohistochemistry Anti-phoshpho-TIE2 (pTyr1108): Cat. No. SAB4503999: Immunohistochemistry analysis of paraffin-embedded Human Non-Hodgkin′s lymphoma.
Immunohistochemistry Anti-phoshpho-TIE2 (pTyr1108): Cat. No. SAB4503999: Immunohistochemistry analysis of paraffin-embedded Human ovary carcinoma.
Immunohistochemistry Anti-phoshpho-TIE2 (pTyr1108): Cat. No. SAB4503999: Immunohistochemistry analysis of paraffin-embedded Human prostate carcinoma.
Immunohistochemistry Anti-phoshpho-TIE2 (pTyr1108): Cat. No. SAB4503999: Immunohistochemistry analysis of paraffin-embedded Human stomach carcinoma.
Immunohistochemistry Anti-phoshpho-TIE2 (pTyr1108): Cat. No. SAB4503999: Immunohistochemistry analysis of paraffin-embedded Human tonsil tissue.
Western Blotting Anti-phoshpho-TIE2 (pTyr1108): Cat. No. SAB4503999: Western blot analysis of extracts from NIH-3T3 cells.
ELISA Anti-phoshpho-TIE2 (pTyr1108): Cat. No. SAB4503999: ELISA for Immunogen Phosphope(pTide (left) and Non-Phosphope(pTide (right).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 125 kDa |
| NCBI accession no. | Q02763   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, rat, human |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr1108) |
| technique(s) | ELISA: 1:10000 |
| immunofluorescence: 1:100-1:500 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | Q02763 |
| Biochem/physiol Actions: | Tie-2 (TEK receptor tyrosine kinase) protein induces angiogenesis and supports endothelial cell survival, upon binding of angiopoietin-1 (an endothelial growth factor) to the receptor. This gene is necessary for Schlemm′s canal formation. This gene regulates vascular homeostasis by involving in auto or transphosphorylation. Tie-2 is essential for the growth of vascular structures during embryogenesis. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | The TIE2 (TEK receptor tyrosine kinase) is also termed as TEK (tyrosine-protein kinase receptor). This gene is located on human chromosome 9p21.2. It is expressed in the Schlemm′s canal endothelial of the eye. TIE2 belongs to the receptor tyrosine kinases family. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human TIE2 around the phosphorylation site of Tyr1108. Immunogen Range: 1074-1123 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |