Anti-phospho-Period Circadian Protein 2 (pSer662) antibody produced in rabbit
SIGMA/SAB4504313 - affinity isolated antibody
Product Type: Chemical
Western Blotting Anti-phoshpho-Period Circadian Protein 2 (pSer662): Cat. No. SAB4504313: Western blot analysis of extracts from NIH-3T3 cells treated with 125 ng/mL PMA for 30 minutes.
ELISA Anti-phoshpho-Period Circadian Protein 2 (pSer662): Cat. No. SAB4504313: ELISA for Immunogen Phosphope(pTide (left) and Non-Phosphope(pTide (right).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 136 kDa |
| NCBI accession no. | O15055   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, mouse |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer662) |
| technique(s) | ELISA: 1:5000 |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | O15055 |
| Biochem/physiol Actions: | PER2 (period circadian regulator 2) possess a physiological and pathological control over the mammalian circadian clock. Abnormal expression of PER2 gene leads to the development of a variety of cancer. Loss of PER2 gene function is observed in the onset of oral squamous cell carcinoma. PER2 might act as an essential biomarker for the same. The reciprocal negative regulation loop of PER2 modulates hepatic circadian clock and the process of aging. PER2 is associated with the pathogenesis of rheumatoid arthritis. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | The PER2 (period circadian regulator 2) gene is mapped to human chromosome 2q37.3. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human Period Circadian Protein 2 around the phosphorylation site of Ser662. Immunogen Range: 636-685 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |