Anti-phospho-VEGFR2 (pTyr1175) antibody produced in rabbit
SIGMA/SAB4504567 - affinity isolated antibody
Synonym: Anti-CD309; Anti-FLK1; Anti-VEGFR; Anti-VEGFR2
Product Type: Chemical
Immunohistochemistry Anti-phoshpho-VEGFR2 (pTyr1175): Cat. No. SAB4504567: Immunohistochemistry analysis of paraffin-embedded Human brain gliomas.
Immunohistochemistry Anti-phoshpho-VEGFR2 (pTyr1175): Cat. No. SAB4504567: Immunohistochemistry analysis of paraffin-embedded Human colon carcinoma.
Immunohistochemistry Anti-phoshpho-VEGFR2 (pTyr1175): Cat. No. SAB4504567: Immunohistochemistry analysis of paraffin-embedded Human kidney carcinoma.
Western Blotting Anti-phoshpho-VEGFR2 (pTyr1175): Cat. No. SAB4504567: Western blot analysis of extracts from HuvEc cells and NIH-3T3 cells.
ELISA Anti-phoshpho-VEGFR2 (pTyr1175): Cat. No. SAB4504567: ELISA for Immunogen Phosphope(pTide (left) and Non-Phosphope(pTide (right).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 151 kDa |
| NCBI accession no. | P35968   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, rat, mouse |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr1175) |
| technique(s) | ELISA: 1:10000 |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P35968 |
| Application: | Anti-phospho-VEGFR2 (pTyr1175) antibody has been used in immunoblotting. |
| Biochem/physiol Actions: | The immunoglobulin-like (Ig-like) domains of the vascular endothelial growth factor receptor-2 (VEGFR-2) are essential for specific ligand binding and receptor dimerization. It helps to activate multiple signaling cascades. VEGF-KDR participates in angiogenesis. VEGFR2 is involved in progression of several cancers like gliomas, malignant peripheral nerve sheath tumors, triple-negative breast cancer (TNBC) and gastrointestinal stromal tumors (GISTs). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | The vascular endothelial growth factor receptor-2 (VEGFR-2) is also called as kinase insert domain containing receptor (KDR). There are seven immunoglobulin-like (Ig-like) domains at the extracellular region (EC) of VEGFR-2. This gene is mapped to human chromosome 4q12. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human VEGFR2 around the phosphorylation site of Tyr1175. Immunogen Range: 1141-1190 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |