Monoclonal Anti-CD105 antibody produced in mouse
SIGMA/SAB4700262 - clone MEM-229, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-ENG; Anti-Endoglin
Product Type: Chemical
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| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | MEM-229, monoclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| isotype | IgG2a |
| NCBI accession no. | NM_000118.2   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, pig |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| technique(s) | flow cytometry: suitable |
| UniProt accession no. | P17813 |
| Application: | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Flow cytometry/Cell sorting (1 paper) |
| Biochem/physiol Actions: | CD105/ endoglin (ENG) acts as an accessory receptor within transforming growth factor (TGF)-β signalling pathway. It is implicated in the regulation of TGF-β-dependent cellular responses. The protein expressed in endothelial cells plays a vital role in angiogenesis and tumour progression. CD105 functions as a potential target of epigenetic silencing in lung cancer. Deletion of the gene leads to hereditary hemorrhagic telangiectasia. In addition, mutations in the gene is also associated with various cardiovascular anomalies and different types of cancers. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
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| General description: | CD105, also known as endoglin (ENG) gene is mapped to human chromosome 9q34.11. The gene codes for a homodimeric transmembrane coreceptor containing disulfide-linked subunits of 95kDa. The encoded protein is mainly expressed on human pre-erythroblasts, macrophages, leukemic cells of the lymphoid and myeloid lineages. It is also present at higher levels on syncytiotrophoblasts of term placenta and vascular endothelial cells. |
| General description: | The antibody MEM-229 recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy. |
| Immunogen: | Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA |
| Physical form: | Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide. |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352203 |