Monoclonal Anti-CD42b antibody produced in mouse
SIGMA/SAB4700290 - clone HIP1, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-GP1BA; Anti-GPIb α
Product Type: Chemical
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | HIP1, monoclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| isotype | IgG1 |
| NCBI accession no. | NM_000173.5   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, nonhuman primates |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| technique(s) | flow cytometry: suitable |
| UniProt accession no. | P07359 |
| Application: | The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2-8 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator. |
| Biochem/physiol Actions: | Cluster of differentiation 42b (CD42b) clustering promotes integrin αIIbβ3-dependent platelet aggregation, phagocytosis and rapid platelet clearance in the liver. The encoded protein acts as a platelet receptor for von Willebrand factor (VWF) and other ligands present in circulation. Mutation in the gene leads to autosomal recessive Bernard-Soulier syndrome. CD42b interacts with plasma hemoglobin (Hb) and enhances platelet activation and apoptosis in a concentration-dependent manner and also regulates platelet functions. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Cluster of differentiation 42b (CD42b), also known as, glycoprotein Ib platelet α subunit (GP1BA), is encoded by the gene mapped to human chromosome 17p13.2. |
| General description: | The antibody HIP1 reacts with CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa); CD42b/c forms a noncovalent complex with CD42a and CD42d. |
| Immunogen: | Peripheral blood mononuclear cells of a patient suffering with CLL |
| Physical form: | Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide. |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352203 |