Monoclonal Anti-CD326-FITC antibody produced in mouse
SIGMA/SAB4700424 - clone VU-1D9, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-EPCAM
Product Type: Chemical
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| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | VU-1D9, monoclonal |
| conjugate | FITC conjugate |
| form | buffered aqueous solution |
| isotype | IgG1 |
| NCBI accession no. | NM_002354.2   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| technique(s) | flow cytometry: suitable |
| UniProt accession no. | P16422 |
| Application: | The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests. |
| Biochem/physiol Actions: | Cluster of differentiation 326 (CD326) is a transmembrane glycoprotein, involved in several cellular functions, such as epithelial-specific intercellular cell–adhesion, cell signaling, migration, proliferation and differentiation. CD326 is a dominant surface antigen mapped on human colon carcinoma. It has potential as a diagnostic marker for several carcinomas, including epithelial ovarian cancer (EOC). CD326 is considered to be a potential target for cancer treatment. CD326 with the help of components of wnt signal transduction pathway plays a vital role in stem cell signaling. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Epithelial cell adhesion molecule (EpCAM) or cluster of differentiation 326 (CD326), is encoded by the 14kb GA733-2 gene mapped to human chromosome 2p21. Human CD326 expression is restricted to epithelia of colon, small intestine, lung, kidney, thymus, liver, pancreas, stomach. It is also expressed in several cancers, progenitor and stem cells. CD326 is a transmembrane glycoprotein characterized with an ectodomain, one transmembrane domain and a 26 residual cytoplasmic domain. |
| General description: | The mouse monoclonal antibody VU-1D9 recognizes an epitope within EGF-like domain I of CD326 / EpCAM, a marker of epithelial lineages. This antibody strongly stains various normal epithelial cells and carcinomas. |
| Immunogen: | Small cell lung carcinoma cell line H69 |
| Physical form: | Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent. |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352203 |