Monoclonal Anti-CD71 antibody produced in mouse
SIGMA/SAB4700520 - clone MEM-189, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-TFRC; Anti-Transferrin Receptor
Product Type: Chemical
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| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | MEM-189, monoclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| isotype | IgG1 |
| NCBI accession no. | NM_001128148.1   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| technique(s) | flow cytometry: suitable |
| UniProt accession no. | P02786 |
| Application: | The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator. |
| Biochem/physiol Actions: | Cluster of differentiation 71 (CD71) functions as an iron regulatory protein. Overexpression of the gene has been associated with the development of various types of cancers, including cholangiocarcinoma (CCA). Thus, CD71 protein is considered as a potential therapeutic target for CCA and iron overload. The encoded protein facilitates mitochondrial respiration and reactive oxygen species (ROS) production in human pancreatic ductal adenocarcinoma (PDAC) cells, which is essential for their tumorigenic growth. Thus, aberrant expression of CD71 might also lead to the development of pancreatic cancer. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Cluster of differentiation 71 (CD71), also known as transferrin receptor, is encoded by the gene mapped to human chromosome 3q29. CD71 is present on cells with high proliferation. |
| General description: | The antibody MEM-189 reacts with CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes. |
| Immunogen: | KG1 human acute myelogenous leukaemia cell line |
| Physical form: | Solution in Tris buffered saline, pH 8.0, with 15 mM sodium azide. |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352203 |