Monoclonal Anti-MDC1 antibody produced in mouse
SIGMA/SAB5200020 - clone P2B11, 1 mg/mL, purified immunoglobulin
Synonym: Anti-MDC1, P2B11; Anti-Nuclear factor with BRCT domains1; Anti-mediator of DNA damage checkpoint 1
Product Type: Chemical
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | P2B11, monoclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous glycerol solution |
| isotype | IgG1 |
| mol wt | antigen predicted mol wt 184 kDa |
| NCBI accession no. | NP_001010833.2   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, mouse, bovine, chimpanzee |
| storage temp. | −20°C |
| technique(s) | indirect immunofluorescence: suitable |
| western blot: suitable | |
| UniProt accession no. | Q14676 |
| Biochem/physiol Actions: | Mediator of DNA damage checkpoint 1 (MDC1) plays a vital role in stimulation of the intra–S phase and G2-M phase checkpoints of the cell cycle in response to DNA damage. Polymorphism of the gene has been associated with the development of both the serum LDL-cholesterol concentration and hyper–LDL-cholesterolemia |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Mediator of DNA damage checkpoint 1 (MDC1) is a nuclear protein that in humans is encoded by the MDC1 gene mapped to chromosome 6p21.33. The encoded protein is widely expressed in various types of tissues and organs. MDC1 is characterized with two BRCA1 C terminus (BRCT) domain, an N-terminal phosphoamino-acid-binding motif called a forkhead-associated (FHA) domain and large central proline/serine/threonine- |
| Immunogen: | GST-tagged recombinant protein corresponding to mouse MDC1 ar and around the N-termius |
| Physical form: | Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide |
| Specificity: | Detects ~184 kDa. This antibody recognizes MDC1 at and around the N-terminus. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |