Monoclonal Anti-KCNB1 antibody produced in mouse
SIGMA/SAB5200077 - clone S89-34, 1 mg/mL, purified immunoglobulin
Synonym: Anti-DRK1PC; Anti-Kcnb1; Anti-Kcr1-1; Anti-Kv2.1; Anti-Kv2.1, S89-34; Anti-Shab
Product Type: Chemical
Immunohistochemistry Monoclonal Anti-KCNB1, Clone S89-34: Cat. No. SAB5200077: Immunohistochemistry of KCNB1 on mouse brain hippocampus. Immunohistochemistry shows strong membrane staining of neurons. White matter appears to be negative.
Immunoblotting Monoclonal Anti-KCNB1, Clone S89-34: Cat. No. SAB5200077: Western Blot analysis of KCNB1 on rat brain membrane tissues using a 1:1,000 antibody dilution.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | S89-34, monoclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous glycerol solution |
| isotype | IgG1 |
| mol wt | antigen predicted mol wt 105-125 kDa |
| NCBI accession no. | NP_037318   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| immunoprecipitation (IP): suitable | |
| western blot: suitable | |
| UniProt accession no. | Q14721 |
| Biochem/physiol Actions: | Detects ~105-125 kDa (varies with cell background due to phosphorylation). No crossreactivity to rat Kv2.2. |
| Biochem/physiol Actions: | Potassium voltage-gated channel subfamily B member 1 (KCNB1) forms microdomains to aid in protein trafficking and has a role in smooth muscle contraction. KCNB1 also takes part in membrane fusion activities. Studies on Chinese hamster ovary (CHO) cells have shown that this protein has a role in apoptosis. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Potassium voltage-gated channel subfamily B member 1 (KCNB1) is widely distributed in the central nervous system. The gene ID for the protein is 25736. |
| Immunogen: | Synthetic peptide amino acids 837-853 (cytoplamsic Cterminus) of rat KV2.1(HMLPGGGAHGSTRDQSI), |
| Physical form: | Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |