Anti-SLC12A3 antibody produced in rabbit
SIGMA/SAB5200104 - 1 mg/mL, affinity isolated antibody
Synonym: Anti-NCC; Anti-Slc12a3
Product Type: Chemical
Immunofluorescence Anti-SLC12A3: Cat. No. SAB5200104: Immunofluorescence analysis of SLC12A3 in rat kidney tissues using a 1:200 antibody dilution. Overlay image of SLC12A3 (green) and DAPI (blue) shown.
Immunoblotting Anti-SLC12A3: Cat. No. SAB5200104: Western Blot analysis of SLC12A3 in rat tissues using a 1:1,000 antibody dilution.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous glycerol solution |
| mol wt | antigen predicted mol wt 160 kDa |
| NCBI accession no. | NP_000330   |
| NP_062218 |
|
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, rat, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | P55017 |
| Biochem/physiol Actions: | Detects ~160 kDa. |
| Biochem/physiol Actions: | Solute carrier family 12 member 3 (SLC12A3) is one of the major components of the sodium chloride reabsorption pathway. It controls the Cl- concentration and is also involved in the transepithelial ion absorption and secretion. Mutations in the gene encoding SLC12A3 have been associated with Gitelman syndrome. |
| Biochem/physiol Actions: | This Na-Cl cotransporter is associated with maintaining blood pressure. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Solute carrier family 12 member 3 (SLC12A3) is also known as thiazide-sensitive Na+-Cl- cotransporter (NCCT). It is expressed in the apical cells of the distal convoluted tubule. The gene encoding this 1021 amino acid protein is localized on human chromosome 16q13. The gene ID for the protein is 6559. |
| Immunogen: | AA74-95 (rat), 76-97 (hum) |
| Physical form: | PBS, 50% glycerol, and 0.09% sodium azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |