Monoclonal Anti-SOX2 antibody produced in mouse
SIGMA/SAB5300177 - clone 10F10, ascites fluid
Synonym: Sox-2; Sox2; lcc; ysb
Product Type: Product-on-demand
antibody form | ascites fluid |
antibody product type | primary antibodies |
biological source | mouse |
clone | 10F10, monoclonal |
conjugate | unconjugated |
isotype | IgG1 |
mol wt | 34 kDa |
Quality Level | 100 |
shipped in | wet ice |
species reactivity | human |
storage temp. | −20°C |
target post-translational modification | unmodified |
technique(s) | direct ELISA: 1:10,000 |
immunohistochemistry: 1:200-1:1,000 | |
indirect immunofluorescence: 1:200-1:1,000 | |
western blot: 1:500-1:2,000 | |
UniProt accession no. | P48431 |
Application: | Monoclonal Anti-SOX2 antibody has been used as a core pluripotency factor to regulate stem cell pluripotency. |
Biochem/physiol Actions: | SOX2 (sex-determining region Y-box 2) down-regulation reduces the stem cell count, that affects breast cancer cells in initiating tumor progression. It participates in chemoresistance and regular lung cancer therapies. In mouse, SOX2 plays an important role in branching morphogenesis and regulating lung epithelial cell differentiation. |
Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
General description: | SOX2 (sex-determining region Y-box 2) is a transcription factor consisting of 317 amino acids. It has an HMG (high mobility group box) domain and is a critical transcription regulator of normal stem cell. It is located on human chromosome 3q26.3. |
Immunogen: | Purified recombinant fragment of human SOX2 expressed in E.coli. Mouse monoclonal antibody raised against SOX2 |
Physical form: | Ascitic fluid containing 0.03% sodium azide. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −20°C |
UNSPSC | 12352203 |