Monoclonal Anti-SMN1 antibody produced in mouse
SIGMA/SAB5300203 - clone 2F1, ascites fluid
Synonym: SMA; SMA1; SMA2; SMA3; SMN
Product Type: Product-on-demand
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| antibody form | ascites fluid |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 2F1, monoclonal |
| conjugate | unconjugated |
| isotype | IgG1 |
| mol wt | 39 kDa |
| NCBI accession no. | NM_000344.3   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | monkey, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | direct ELISA: 1:10,000 |
| flow cytometry: 1:200-1:400 | |
| immunohistochemistry: 1:200-1:1,000 | |
| western blot: 1:500-1:2,000 |
| Biochem/physiol Actions: | Survival motor neuron 1 (SMN1) is involved in the synthesis of full length survival motor neuron (SMN) mRNA transcripts. SMN1 also contributes to the biogenesis and assembly of snRNP (small nuclear riboproteins) in the cytoplasm, which plays an important role in pre-mRNA splicing or processing. Axonal SMN protein mediates the growth of axon and mRNA axonal transport. Mutations in the SMN1 gene has been associated with a genetic neurodegenerative disease called spinal muscular atrophy(SMA). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Survival motor neuron 1 (SMN1), also known as gemin 1, is a survival motor neuron protein, which is highly expressed in spinal cord. SMN1 is localized on the telomeric region of human chromosome 5q13. The 38kDA protein is expressed mostly in nucleus and cytoplasm. |
| Immunogen: | Purified recombinant fragment of human SMN1 expressed in E.coli. Mouse monoclonal antibody raised against SMN1 |
| Physical form: | Ascitic fluid containing 0.03% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |