Anti-BCL-2 Alpha antibody, Rabbit monoclonal
SIGMA/SAB5500014 - recombinant, expressed in proprietary host, clone SP66, affinity isolated antibody
Product Type: Product-on-demand
Immunohistochemistry Anti-BCL-2 alpha: Cat. No. SAB5500014: Immunohistochemistry of BCL-2 alpha in Human tonsil tissue with BCL-2 alpha antibody.
Flow Cytometry Anti-Bcl-2 alpha: Cat. No. SAB5500014: Flow cytometric analysis of Monoconal Rabbit Anti-BCL-2 alpha antibody in MCF7 (green) compare to negative control of Rabbit IgG (blue).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | SP66, monoclonal |
| conjugate | unconjugated |
| isotype | IgG |
| Quality Level | 100  |
| recombinant | expressed in proprietary host |
| shipped in | wet ice |
| species reactivity | human (tested) |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| technique(s) | flow cytometry: 1:100 |
| immunohistochemistry: 1:100 | |
| UniProt accession no. | P10415  |
| Biochem/physiol Actions: | B-cell lymphoma 2 (BCL-2) inhibits apoptosis in cells and has been shown to be upregulated in adenomas. Expression of BCL-2α oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2α protein, whereas the normal or hyperplastic germinal centers are negative. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | B-cell lymphoma 2 (BCL-2) is an anti-apoptotic and target gene of nuclear factor-κB (NF-κB). The protein is expressed in the nuclear envelope, mitochondria and endoplasmic reticulum. The gene encoding BCL-2 is localized on human chromosome 18q21. |
| Immunogen: | Synthetic peptide corresponding to N-terminus of human BCL-2 alpha protein. |
| Physical form: | 0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352203 |