Anti-CD68 antibody, Rabbit monoclonal
SIGMA/SAB5500070 - clone SP251, recombinant, expressed in proprietary host, affinity isolated antibody
Product Type: Product-on-demand
Immunohistochemistry Anti-CD68: Cat. No. SAB5500070: Immunohistochemistry of CD68 in Human tonsil tissue with CD68 antibody.
Flow Cytometry Anti-CD68: Cat. No. SAB5500070: Flow cytometric analysis of Monoconal Rabbit Anti-68 antibody in Raji cells (green) compare to negative control of Rabbit IgG (blue).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | SP251, monoclonal |
| conjugate | unconjugated |
| isotype | IgG |
| Quality Level | 100  |
| recombinant | expressed in proprietary host |
| shipped in | wet ice |
| species reactivity | human (tested) |
| storage temp. | 2-8°C |
| technique(s) | flow cytometry: 1:100 |
| immunohistochemistry: 1:100 | |
| UniProt accession no. | P34810  |
| Application: | Monoclonal Anti-CD68 antibody from rabbit has been used for immunohistochemistry. |
| Biochem/physiol Actions: | CD68 (cluster of differentiation 68), a scavenger receptor, significantly participates in the development of Alzheimer′s disease. CD68 serves as a prognostic marker in tumor cells. Deletion of the gene is known to cause reduction in the bone resorption capacity. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | CD68 is an intracellular glycoprotein mainly expressed on macrophages and monocytes. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is also expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML) (M1-M5 types), and granulocytic sarcoma. CD68 (cluster of differentiation 68) gene is mapped to human chromosome 17p13.1. The gene codes for a glycoprotein, macrosialin. The encoded protein belongs to the family of LAMP (lysosome-associated membrane glycoproteins) proteins. Macrosialin contains a glycosylated mucin-like domain. |
| Immunogen: | Synthetic peptide derived from the internal region of the human CD68 protein. |
| Physical form: | 0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352203 |