Anti-F4/80 antibody, Rabbit monoclonal

SIGMA/SAB5500103 - clone SP115, recombinant, expressed in proprietary host, affinity isolated antibody

Product Type: Product-on-demand

Catalog Number	PKG Qty.	Price	Quantity


45-SAB5500103-100UL	100 µL	$338.00 1/EA		Add To Favorites

Immunohistochemistry Anti-F4/80: Cat. No. SAB5500103: Immunohistochemistry of F4/80 in Mouse liver tissue with F4/80 antibody.

Properties
Descriptions
Safety Info.
Basic Data

antibody form	affinity isolated antibody
antibody product type	primary antibodies
biological source	rabbit
clone	SP115, monoclonal
conjugate	unconjugated
isotype	IgG
Quality Level	100
recombinant	expressed in proprietary host
shipped in	wet ice
species reactivity	mouse (tested)
species reactivity (predicted by homology)	rat
storage temp.	2-8°C
target post-translational modification	unmodified
technique(s)	immunohistochemistry: 1:100

Application:	Anti-F4/80 antibody has been used in immunohistochemistry.
Biochem/physiol Actions:	In liquid bone marrow cultures, F4/80/EMR1 (egf-like module containing, mucin-like, hormone receptor-like 1) acts as a maturation marker for mononuclear phagocytes. EMR1 can be used as a target molecule in the treatment of individuals suffering from squamous cell carcinoma and eosinophilic disorders.
Disclaimer:	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits:	Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description:	EMR1 (egf-like module containing, mucin-like, hormone receptor-like 1) is a human homolog of F4/80, an eosinophil-specific receptor. It is abundantly expressed on leukocytes. F4/80 is a member of the GPCR superfamily. It has N-terminal EGF (epidermal growth factor)-like domains bound to a seven-span transmembrane (7TM) moiety through a mucin-like spacer domain. This gene is located on human chromosome 19p13.
General description:	Mouse EGF-like module-containing mucin-like hormone receptor-like 1 (EMR1) or cell surface glycoprotein F4/80 is a cell surface glycoprotein and a member of the EGF TM7 family of proteins. It shares 68% overall amino acid identity with human EGF-module-containing-mucin-like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ regulatory T cells.
Immunogen:	Synthetic peptide derived from N-terminus of mouse F4/80 protein.
Physical form:	0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352203

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