Anti-FBXW7 antibody, Rabbit monoclonal
SIGMA/SAB5500104 - recombinant, expressed in proprietary host, clone SP237, affinity isolated antibody
Product Type: Product-on-demand
Immunohistochemistry Anti-FBXW7: Cat. No. SAB5500104: Immunohistochemistry of FBXW7 in Human endometrial adenocarcinoma tissue with FBXW7 antibody.
Flow Cytometry Anti-FBXW7: Cat. No. SAB5500104: Flow cytometric analysis of Monoconal Rabbit Anti-FBXW7 antibody in HL-60 (green) compare to negative control of Rabbit IgG (blue).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | SP237, monoclonal |
| conjugate | unconjugated |
| isotype | IgG |
| Quality Level | 100  |
| recombinant | expressed in proprietary host |
| shipped in | wet ice |
| species reactivity | human (tested) |
| species reactivity (predicted by homology) | rat, mouse |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| technique(s) | flow cytometry: 1:400 |
| immunohistochemistry: 1:100 | |
| UniProt accession no. | Q969H0  |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | F-box/WD repeat-containing protein 7 (Fbxw7) is part of an ubiquitin-protein ligase complex. The complex ubiquitinates and degrades several important oncogenes such as mTOR, MYC, AURKA, JUN, and NOTCH1. Fbxw7 cooperates with PTEN for tumor suppression and is widely expressed in many normal tissues. The loss of fbxw7 is associated with malignant progression in a variety of tumors, including carcinoma of colorectum, lung, stomach, bile duct, endometrium, pancreas, breast and glioblastoma. |
| Immunogen: | Synthetic peptide derived from the internal region of human FBXW7 protein. |
| Physical form: | 0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352203 |