Anti-MCM2 antibody, Rabbit monoclonal
SIGMA/SAB5500142 - clone SP85, recombinant, expressed in proprietary host, affinity isolated antibody
Product Type: Product-on-demand
antibody form | affinity isolated antibody |
antibody product type | primary antibodies |
biological source | rabbit |
clone | SP85, monoclonal |
conjugate | unconjugated |
isotype | IgG |
Quality Level | 100 |
recombinant | expressed in proprietary host |
shipped in | wet ice |
species reactivity | human (tested) |
species reactivity (predicted by homology) | frog, bovine, mouse, rat, dog |
storage temp. | 2-8°C |
technique(s) | flow cytometry: 1:100 |
immunoblotting: 1:100 | |
immunohistochemistry: 1:100 | |
UniProt accession no. | P49736 |
Biochem/physiol Actions: | Mini chromosome maintenance protein 2 (MCM2) is involved in regulating DNA replication, is crucial in the cell cycle. From its localization, CDCL1 is a candidate for an oncogene affected by chromosomal breaks in acute myeloid leukemia (AML). MCM-2 levels are elevated in salivary gland tumors and malignant lesions of the oral cavity. It serves as a marker for the detection of oral squamous cell carcinoma (OSCC). MCM2 overexpression also displays pro-apoptotic and apoptotic. MCM2 is also implicated in nonsyndromic hearing loss. |
Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
General description: | Mini chromosome maintenance protein 2 (MCM2) is a human nuclear protein. This cell-cycle regulatory protein is similar to members of the family of early S-phase proteins and is expressed in four phases of the cell cycle. MCM2 gene is mapped to human chromosome 3q21.3. MCM2 protein is a member of eukaryal MCM2–7 subunits and is expressed in the nucleus and cytoplasm of various tissues. |
Immunogen: | Synthetic peptide derived from internal region of human MCM2 protein. |
Physical form: | 0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | 2-8°C |
UNSPSC | 12352203 |