Anti-TAU antibody, Rabbit monoclonal
SIGMA/SAB5500182 - recombinant, expressed in proprietary host, clone SP70, affinity isolated antibody
Synonym: Anti-DDPAC; Anti-FTDP-17; Anti-MAPTL; Anti-MSTD; Anti-MTBT1; Anti-MTBT2; Anti-PPND; Anti-PPP1R103; Anti-TAU; Anti-tau-40
Product Type: Product-on-demand
Immunohistochemistry Anti-Tau: Cat. No. SAB5500182: Immunohistochemistry of Tau (neuronal marker) in Human breast carcinoma tissue with Tau (neuronal marker) antibody.
Flow Cytometry Anti-Tau: Cat. No. SAB5500182: Flow cytometric analysis of Monoconal Rabbit Anti-Tau (Neuronal Marker) antibody in SH-SY5Y (green) compare to negative control of Rabbit IgG (blue).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | SP70, monoclonal |
| conjugate | unconjugated |
| isotype | IgG |
| Quality Level | 100  |
| recombinant | expressed in proprietary host |
| shipped in | wet ice |
| species reactivity | human (tested) |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| technique(s) | flow cytometry: 1:100 |
| immunohistochemistry: 1:100 | |
| UniProt accession no. | P10636  |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Tau is a neuronal microtubule associated protein found predominantly on axons. The function of rau is to promote tubulin polymerization and stabilize microtubules, but it also serves to link certain signaling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer′s disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate tau. Alternate splicing of tau mRNA and differential phosphorylation contributes to the heterogeneity of Tau. |
| Immunogen: | Synthetic peptide corresponding to N-terminus of human tau protein. |
| Physical form: | 0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352203 |