Anti-Integrin alpha 4 antibody, Rabbit monoclonal
SIGMA/SAB5600078 - recombinant, expressed in HEK 293 cells, clone RM268, purified immunoglobulin
Product Type: Chemical
Immunohistochemistry Immunohistochemical staining of formalin fixed and paraffin embedded Human Tonsil tissue sections using Anti-Integrin alpha 4 Rabbit Monoclonal Antibody (Clone RM268) at a 1:5000 dilution.
Immunoblotting Western Blot of Jurkat cells lysates using Anti-Integrin alpha 4 Rabbit Monoclonal Antibody (Clone RM268) at a 1:1000 dilution.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | recombinant monoclonal |
| RM268, monoclonal | |
| conjugate | unconjugated |
| form | buffered aqueous glycerol solution |
| isotype | IgG |
| NCBI accession no. | 3676   |
| Quality Level | 100 |
| recombinant | expressed in HEK 293 cells |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: 1:1000-1:2000 |
| immunohistochemistry: 1:1000-1:5000 |
| Biochem/physiol Actions: | Integrin subunit α 4 (ITGA4) has a role in bone marrow homing. It associates with the β1 integrin chain and forms the very-late-antigen-4 (VLA-4) complex. The protein also binds to vascular cell adhesion molecule-1, fibronectin and osteopontin (OPN) and modulates the activity of immature progenitors in the bone marrow. ITGA4 also aids the migration of B lymphocytes through the fibroblast barrier. |
| Biochem/physiol Actions: | This antibody reacts to the cytoplasmic domain of human Integrin alpha 4 (ITGA4). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Integrin subunit α4 (ITGA4) is an adhesive factor, that is part of the integrin family. The gene encoding it is localized on human chromosome 2q31.3. |
| Immunogen: | Synthetic peptide corresponding to the C-terminus of human Integrin alpha 4 (ITGA4) |
| Physical form: | Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |