Anti-TRAF2 antibody produced in rabbit
SIGMA/SAB5700018
Synonym: MGC:45012; TRAF2; TRAP; TRAP3
Product Type: Chemical
antibody form | affinity isolated antibody |
antibody product type | primary antibodies |
biological source | rabbit |
clone | polyclonal |
concentration | 2.88 mg/ml |
form | buffered aqueous solution |
mol wt | 53 |
54 | |
55 | |
61 | |
Quality Level | 100 |
shipped in | wet ice |
species reactivity | rat, mouse, human |
storage temp. | −20°C |
technique(s) | immunofluorescence: 1:50-1:100 |
immunoprecipitation (IP): 1:50-1:100 | |
western blot: 1:500-1:2000 | |
UniProt accession no. | Q12933 |
General description: | The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human TRAF2 (NP_066961.2). |
Physical form: | PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Storage and Stability: | Store at -20℃. Avoid freeze / thaw cycles. |
WGK Germany | WGK 1 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −20°C |
UNSPSC | 12352203 |