Anti-Phospho-CHEK1-S280 antibody produced in rabbit
SIGMA/SAB5700286
Synonym: CHEK1; CHK1
Product Type: Chemical
antibody form | affinity isolated antibody |
antibody product type | primary antibodies |
biological source | rabbit |
clone | polyclonal |
concentration | 1.66 mg/ml |
form | buffered aqueous solution |
mol wt | 43 |
50 | |
54 | |
Quality Level | 100 ![]() |
shipped in | wet ice |
species reactivity | mouse, human, rat |
storage temp. | −20°C |
technique(s) | immunofluorescence: 1:50-1:200 |
immunohistochemistry: 1:50-1:200 | |
western blot: 1:200-1:2000 | |
UniProt accession no. | O14757 ![]() ![]() |
General description: | The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. |
Immunogen: | A synthetic phosphorylated peptide around S280 of human CHEK1 (NP_001265.2). |
Physical form: | PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Storage and Stability: | Store at -20℃. Avoid freeze / thaw cycles. |
WGK Germany | WGK 1 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −20°C |
UNSPSC | 12352203 |