Anti-Phospho-PLN-S16 antibody produced in rabbit
SIGMA/SAB5700534
Synonym: CMD1P; CMH18; PLB; PLN
Product Type: Chemical
antibody form | affinity isolated antibody |
antibody product type | primary antibodies |
biological source | rabbit |
clone | polyclonal |
concentration | 0.65 mg/ml |
form | buffered aqueous solution |
mol wt | 6 |
Quality Level | 100 ![]() |
shipped in | wet ice |
species reactivity | rat, mouse, human |
storage temp. | −20°C |
technique(s) | western blot: 1:500-1:2000 |
UniProt accession no. | P26678 ![]() ![]() |
General description: | The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. |
Immunogen: | A phospho specific peptide corresponding to residues surrounding S16 of human PLN |
Physical form: | PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Storage and Stability: | Store at -20℃. Avoid freeze / thaw cycles. |
WGK Germany | WGK 1 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −20°C |
UNSPSC | 12352203 |