Anti-Caspase 1 antibody produced in rabbit
SIGMA/SAB5700660
Synonym: CASP1; Caspase 1; ICE; IL1BC; P45; caspase-1
Product Type: Chemical
antibody form | affinity isolated antibody |
antibody product type | primary antibodies |
biological source | rabbit |
clone | polyclonal |
concentration | 1.96 mg/ml |
form | buffered aqueous solution |
mol wt | 10 |
29 | |
35 | |
42 | |
45 | |
Quality Level | 100 ![]() |
shipped in | wet ice |
species reactivity | rat, human, mouse |
storage temp. | −20°C |
technique(s) | immunofluorescence: 1:50-1:200 |
immunohistochemistry: 1:50-1:200 | |
immunoprecipitation (IP): 1:50-1:100 | |
western blot: 1:500-1:2000 | |
UniProt accession no. | P29466 ![]() ![]() |
General description: | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-311 of human Caspase-1 (NP_150635.1). |
Physical form: | PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Storage and Stability: | Store at -20℃. Avoid freeze / thaw cycles. |
WGK Germany | WGK 1 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −20°C |
UNSPSC | 12352203 |