Anti-RCC1 antibody produced in rabbit
SIGMA/SAB5700887
Product Type: Chemical
antibody product type | primary antibodies |
biological source | rabbit |
clone | monoclonal |
concentration | 0.51 mg/mL |
form | liquid |
Quality Level | 100 ![]() |
shipped in | wet ice |
species reactivity | human, rat, mouse |
storage temp. | −20°C |
technique(s) | immunohistochemistry: 1:50-1:100 |
immunohistochemistry: 1:50-1:200 | |
western blot: 1:500-1:2000 | |
UniProt accession no. | P18754 ![]() ![]() |
General description: | Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:1944575, PubMed:17435751, PubMed:20668449, PubMed:22215983, PubMed:11336674). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580). |
Immunogen: | A synthesized peptide derived from human RCC1 |
Physical form: | Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |
Storage Temp. | −20°C |