Anti- Bax antibody produced in rabbit
SIGMA/SAB5701392
Product Type: Chemical
antibody product type | primary antibodies |
biological source | rabbit |
clone | monoclonal |
concentration | 1 mg/mL |
form | liquid |
Quality Level | 100 ![]() |
shipped in | wet ice |
species reactivity | rat, human |
storage temp. | −20°C |
technique(s) | immunohistochemistry: 1:50-1:200 |
western blot: 1:500-1:2000 | |
UniProt accession no. | Q07812 ![]() ![]() |
General description: | The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. |
Immunogen: | A synthetic peptide of human Bax. |
Physical form: | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Storage Temp. | −20°C |